Dexmedetomidine mitigates myocardial ischemiareperfusion injury via regulation of HMGB1-TLR4-NF-κB signaling axis
نویسندگان
چکیده
Purpose: To study the effect of dexmedetomidine (Dex) on myocardial ischemia-reperfusion injury (MIRI), and associated mechanism action.Methods: Sixty Sprague-Dawley (SD) rats were assigned to sham, (I/R), Dex, MD groups (methyllycaconitine prior injection with Dex), 15 in each group. Pathological changes tissues determined all groups. Protein expression levels HMGB1, TLR4, NF-κB myeloid differentiation protein 88 (MyD88) serum assayed compared.Results: MyD88 significantly higher heart muscle I/R than those sham group, but lower Dex group (p < 0.05). However, they up-regulated relative (p< 0.05).Conclusion: exerts a protective against ischemia/reperfusion-induced damage via HMGB1-TLR4-NF-κB signal axis CAP, thus, is potential agent for management disease.
منابع مشابه
Dexmedetomidine preconditioning may attenuate myocardial ischemia/reperfusion injury by down-regulating the HMGB1-TLR4-MyD88-NF-кB signaling pathway
AIMS To investigate whether dexmedetomidine (DEX) preconditioning could alleviate the inflammation caused by myocardial ischemia/reperfusion (I/R) injury by reducing HMGB1-TLR4-MyD88-NF-кB signaling. METHODS Seventy rats were randomly assigned into five groups: sham group, myocardial I/R group (I/R), DEX+I/R group (DEX), DEX+yohimbine+I/R group (DEX/YOH), and yohimbine+I/R group (YOH). Animal...
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ژورنال
عنوان ژورنال: Tropical Journal of Pharmaceutical Research
سال: 2021
ISSN: ['1596-5996', '1596-9827']
DOI: https://doi.org/10.4314/tjpr.v20i11.6